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目的探讨恶性淋巴瘤(ML)发生的危险因素。方法采用以医院病例为基础的1:2配比病例对照研究方法,对从江苏省南通市4家医院收集的72例经组织病理学确诊的恶性淋巴瘤(ML)患者及144例其他肿瘤和非肿瘤对照进行问卷调查。采用多分类结局Logistic回归分析模型拟合的方法,单因素和多因素分析ML的相关因素。结果住所周围环境污染(OR=2.747,90%CI=1.216～6.204)、经常接触有机溶剂(OR=4.310,90%CI=1.079～17.219)、经常接触化肥农药(OR=2.648,90%CI=1.188～5.903)、本人其他肿瘤史(OR=7.586,90%CI=1.202～47.890)、家族肿瘤史(OR=5.268,90%CI=2.054～13.515)等5个因素可能增加ML的危险性;而经常吃淡水鱼虾(OR=0.456,90%CI=0.246～0.842)可降低ML的危险性。结论恶性淋巴瘤影响因素较为复杂,环境污染、化学毒物接触及家族史是主要危险因素。
Objective To investigate the risk factors of malignant lymphoma (ML). Methods A case-control study based on a 1: 2 ratio of hospital cases was performed in 72 patients with pathologically confirmed malignant lymphoma (ML) and 144 other tumors collected from 4 hospitals in Nantong City, Jiangsu Province. Non-tumor control questionnaire. Logistic regression was used to analyze the model fitting method using multiple classification of outcomes, and univariate and multivariate analysis of the relevant factors of ML. The results showed that the environment around the residence was polluted (OR = 2.747,90% CI = 1.216 ~ 6.204), and had frequent exposure to organic solvents (OR = 4.310, 90% CI = 1.079-17.219) (OR = 7.586,90% CI = 1.202 ~ 47.890) and family history of cancer (OR = 5.268,90% CI = 2.054 ~ 13.515) While eating freshwater fish and shrimp regularly (OR = 0.456,90% CI = 0.246 ~ 0.842) can reduce the risk of ML. Conclusion The influencing factors of malignant lymphoma are complex, and environmental pollution, exposure to chemical poisons and family history are the main risk factors.