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头孢噻肟钠是第三代头孢菌素类抗生素,与β-内酰胺酶抑制剂结合可以抵抗耐药菌发挥药效。文中对国内外各研究机构在头孢噻肟钠/舒巴坦钠、头孢噻肟钠/他唑巴坦钠两个复方抗生素的药学分析、体内外药效学研究、药动学研究、耐受性研究、临床研究以及不良反应报告等方面的研究做一综述。
Cefotaxime sodium is the third generation cephalosporin antibiotics, combined with β-lactamase inhibitor can resist drug-resistant bacteria play a pharmacodynamic effect. In this paper, the domestic and foreign research institutions in the cefotaxime sodium / sulbactam sodium, cefotaxime sodium / tazobactam sodium two antibiotic pharmaceutical analysis, pharmacodynamics studies in vitro and in vivo, pharmacokinetic studies, tolerance Sex research, clinical research and adverse reaction reports.