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目的：研究一类新型的三氮唑化合物对念珠菌属真菌的抗真菌活性。方法：采用体外抗真菌活性试验， 测定化合物的最低抑菌浓度（ Ｍ Ｉ Ｃ），从而评价化合物的生物活性作用。结果：所有２４ 个新的化合物对念珠菌属真菌均有不同的抑制作用，其中对白念珠菌的活性最好。化合物 １２ 对白念珠菌的活性最强，是标准对照品氟康唑的２５６ 倍。化合物１７ 对耐氟康唑的白念珠菌的活性最强，是标准对照品氟康唑的１６ 倍。结论：化合物 １２ 和１７ 可以作为两个潜在的药物进一步进行研究。
Objective: To study the antifungal activity of a new class of triazole compounds against Candida fungi. Methods: The antimicrobial activity test in vitro was used to determine the minimum inhibitory concentration (M I C) of the compound to evaluate the bioactivity of the compound. Results: All 24 new compounds had different inhibitory effects on Candida fungi, of which Candida albicans was the best. Candida albicans was the most active against compound 12, 256 times more than fluconazole, a standard reference compound. Compound 17 was the most potent against fluconazole-resistant Candida albicans, 16 times more potently as compared to the standard reference fluconazole. Conclusion: Compounds 12 and 17 can be further investigated as two potential drugs.