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[目的]探讨乳腺肿瘤组织中p 53基因的表达情况及其意义.[方法]利用免疫组织化学技术观察62例乳腺癌及14例乳腺纤维腺瘤中突变型p 53基因的表达情况.[结果]乳腺癌组织中的p53基因表达率明显高于乳腺纤维腺瘤;Ⅲ期乳腺癌组织中p53基因的表达率高于I期及Ⅱ期,且Ⅲ期与I期及Ⅱ期之间均各有显著性差异,与TNM分期呈正相关;p53基因的表达与乳腺肿瘤的组织学类型、组织学分级、淋巴结转移、ER及PR状况、年龄及家族史之间均无相关关系;朝鲜族与汉族之间亦无显著性差异.[结论]p 53基因的表达可作为判断乳腺癌及TNM分期的指标.
[Objective] To investigate the expression of p 53 gene in breast cancer tissues and its significance. [Methods] Immunohistochemical technique was used to observe the expression of mutant p 53 gene in 62 cases of breast cancer and in 14 cases of breast fibroadenoma. [Results] ] The expression of p53 gene in breast cancer tissues was significantly higher than that in breast fibroadenoma. The expression of p53 gene in stage Ⅲ breast cancer tissues was higher than that in stage I and stage II, and between stage III and stage I and stage II There was a significant difference between them and TNM staging. There was no correlation between p53 gene expression and histological types, histological grade, lymph node metastasis, ER and PR status, age and family history of breast cancer. There was no significant difference between the two groups. [Conclusion] The expression of p 53 gene can be used as an index to determine the stage of breast cancer and TNM.