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目的探讨H型高血压与老年脑梗塞的相关性。方法选取潍坊市人民医院2011年10月~2012年10月收治的121例老年(均年龄≥60岁)原发性高血压(EH)高血压合并脑梗塞患者为研究对象,其中按照高血压同型半胱氨酸(Hcy)水平是否≥10μmol/L,将其分为H型高血压组(H型组)59例和单纯性高血压组(单纯组)61例,根据患者颅脑CT或MRI是否有梗塞灶,分为脑梗塞组和非脑梗组。并测三酰甘油(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)等生化指标及收集年龄、性别、吸烟史、饮酒史等流行病学资料。结果脑梗塞组患者的Hcy水平显著高于非脑梗组(P<0.01);且H型组较单纯组脑梗塞患者病例数高(P<0.05);经Person相关性分析示:r=0.25,P<0.01,说明H型高血压与老年脑梗塞的发病有一定的相关性,可能是老年脑梗塞发生的危险因子。结论 H型高血压与老年脑梗塞的的高发生率有关,降低Hcy水平可能使我国脑梗死的高发生率得到改善。
Objective To investigate the relationship between Hypertension and cerebral infarction in the elderly. Methods A total of 121 elderly patients (≥60 years old) with essential hypertension (EH) complicated with cerebral infarction who were admitted to Weifang People’s Hospital from October 2011 to October 2012 were enrolled in this study. Hypertension 59 cases of H type hypertension group and 61 cases of simple hypertension group (simple group) according to whether the level of Hcy was ≥10μmol / L or not. According to the patients’ brain CT or MRI Whether there is infarction, divided into cerebral infarction group and non-cerebral infarction group. The biochemical indexes such as TG, TC, LDL-C and HDL-C were also collected to collect epidemiological data such as age, gender, smoking history and drinking history Learn information Results The level of Hcy in cerebral infarction group was significantly higher than that in non-cerebral infarction group (P <0.01), and the number of patients in H group was higher than that in simple cerebral infarction group (P <0.05). Person-related analysis showed that: , P <0.01, indicating that Hypertension and the incidence of cerebral infarction have a certain correlation, may be risk factors for the occurrence of cerebral infarction in the elderly. Conclusions Hypertension is associated with a high incidence of cerebral infarction in the elderly. Decreasing Hcy levels may improve the high incidence of cerebral infarction in China.