目的分析研究了米非司酮联合甲基睾丸素对围绝经期功能失调性的子宫出血患者的治疗效果,以期可以为临床治疗提供必要的借鉴和指导。方法选择了2010年5月~2012年5月在我院治疗的围绝经期功能失调性子宫出血的患者100例进行研究,采取随机分组的方法将患者分为对照组50例,观察组50例。对照组患者采取妈富隆开展治疗,而观察组的患者则采取米非司酮联合甲基睾丸素联合治疗的方法。三个月为一个疗程,在一个疗程结束之后对两组患者的子宫内膜厚度、性激素下降情况以及临床症状进行了对比性分析。结果两组患者在经过3个月的治疗之后,观察组患者的子宫内膜厚度、性激素下降情况以及临床症状都要明显优于对照组,且结果(P<0.05)具有统计学意义,另外观察组患者在用药之后的复发情况和不良反应情况也要优于对照组,且结果(P<0.05)具有统计学意义。结论女性围绝经期功能失调性的子宫出血使用米司非酮联合甲基睾丸素联合用药开展治疗具有比较好的临床效果。采取此方法具有安全有效、不良反应复发率低等一些基本特点,值得在临床上进行应用推广。 Objective To analyze the curative effect of mifepristone combined with methyltestosterone on uterine bleeding in patients with peri-menopausal dysfunction, so as to provide the necessary reference and guidance for clinical treatment. Methods A total of 100 patients with peri-menopausal dysfunctional uterine bleeding treated in our hospital from May 2010 to May 2012 were selected and randomly divided into control group (n = 50) and observation group (n = 50) . Patients in the control group were treated with Marvelon, while patients in the observation group were treated with mifepristone combined with methyltestosterone. Three months for a course of treatment, at the end of a course of treatment of two groups of patients with endometrial thickness, sex hormone decline and clinical symptoms were compared. Results After 3 months of treatment, the endometrial thickness, the decline of sex hormones and the clinical symptoms of the observation group were significantly better than those of the control group. The results (P <0.05) were statistically significant, the other observation The recurrence and adverse reactions of the patients after treatment were also better than the control group, and the results (P <0.05) were statistically significant. Conclusion Female perimenopausal dysfunctional uterine bleeding using mifepristone combined with methyltestosterone for treatment has a good clinical effect. To take this method is safe and effective, the recurrence rate of adverse reactions and some of the basic features, it is worth in the clinical application and promotion.