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目的:探讨血清氧化低密度脂蛋白(ox-LDL)和脂蛋白相关磷脂酶A2(Lp-PLA2)水平与急性脑梗死(ACI)患者TOAST病因分型及病情程度的关系。方法:选取2015年1月至2016年1月在深圳市第二人民医院神经内科住院治疗的急性缺血性卒中患者200例,进行TOAST分型(分成5个主要亚型,即大动脉粥样硬化型(LAA)、小动脉闭塞型(SAO)、心源性栓塞型(CE)、其他明确病因型(SOE)和不明原因型(SUE)及NHISS评分界定神经功能缺损程度分组(分为轻度神经功能缺损(<4分),中度神经功能缺损(4~15分),重度神经功能缺损(>15分),检测患者血清ox-LDL和Lp-PLA2水平,将结果进行统计学分析。结果:脑梗死TOAST分型中LAA及SAO组ox-LDL和Lp-PLA2水平高于对照组及其他亚型组,差异具有统计学意义(P<0.01)。脑梗死神经功能缺损中、重度组ox-LDL和Lp-PLA2水平明显高于轻度组,差异具有统计学意义(P<0.01);结论:联合应用ox-LDL及Lp-PLA2可以作为评判ACITOAST病因分型和疾病严重程度的重要和可靠的参考指标。
Objective: To investigate the relationship between serum oxidized low-density lipoprotein (ox-LDL) and lipoprotein-associated phospholipase A2 (Lp-PLA2) in patients with acute cerebral infarction (ACI) Methods: A total of 200 acute ischemic stroke patients hospitalized in Department of Neurology, Second People ’s Hospital of Shenzhen from January 2015 to January 2016 were selected for TOAST classification (divided into five major subtypes, namely, atherosclerosis LAA, SAO, CE, other SOEs, SUE and NHISS scores were divided into four groups: mild The neurological deficits (<4 points), moderate neurological deficits (4 to 15 points), severe neurological deficits (> 15 points) were measured. The serum levels of ox-LDL and Lp-PLA2 were measured and the results were statistically analyzed. Results: The levels of ox-LDL and Lp-PLA2 in LAA and SAO group were higher than those in control group and other subtypes in TOAST classification, the difference was statistically significant (P <0.01) ox-LDL and Lp-PLA2 levels were significantly higher than those in mild group (P <0.01) .Conclusion: Combination of ox-LDL and Lp-PLA2 can be used as an important factor to judge the etiology and severity of ACITOAST And reliable reference index.