自身免疫异常在现代免疫学中是重要的研究课题之一,作者通过动物模型和临床实验资料证明:自身免疫异常的发病机制与病毒感染有关。用 C 型 RNA 病毒、DNA 病毒分别感染马、水貂、狗及小鼠后,分别引起了 Coombs 阳性的溶血性贫血、肝炎及肾小球肾炎或者出现红斑狼疮(LE)细胞、红斑、血小板减少、DNA 抗体等系统性红斑狼疮(SLE)样病变。将出现了 SLE 症状的狗其脾组织匀浆接种给新生的狗及小白鼠后,同样出现了上述SLE 症状。作者在研究小鼠的病毒感染与免疫异常时发现在 Autoimmune disorders in modern immunology is one of the important research topics, the author of animal models and clinical data show that: the pathogenesis of autoimmune diseases and viral infection. Coombs-positive hemolytic anemia, hepatitis and glomerulonephritis, or lupus erythematosus (LE) cells, erythema, and thrombocytopenia were induced in mice, minks, dogs and mice respectively after infection with type C RNA viruses and DNA viruses. DNA antibodies and other systemic lupus erythematosus (SLE) -like lesions. SLE symptoms will appear in dogs with their spleen homogenate after inoculation of newborn dogs and mice, also appeared in the SLE symptoms. The authors found in studying the virus infection and immune abnormalities in mice