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目的:分析莫西沙星致肝损害的病例报告,为临床合理用药提供参考。方法:检索国内外医药数据库,下载莫西沙星致肝损害的病例报告原文进行统计分析。结果:莫西沙星致肝损害16例,其中男性12例,中老年患者14例;肝损害类型以胆汁淤积型多见;致肝损害主要与过敏机制参与有关。经停药与保肝等对症治疗,11例恢复正常,1例失访,1例肝移植存活,3例死亡。结论:莫西沙星引起的肝损害可致死亡,医务人员应高度重视莫西沙星的这种严重不良反应。
Objective: To analyze the case reports of moxifloxacin-induced liver damage and provide reference for clinical rational drug use. Methods: Retrieve domestic and foreign medical database, download the report of Moxifloxacin-induced liver damage for statistical analysis. Results: Moxifloxacin induced liver damage in 16 cases, including 12 males and 14 middle-aged and elderly patients. The types of liver damage were more common in cholestasis. The liver damage was mainly related to the involvement of allergic mechanisms. After stopping treatment and keeping the liver and other symptomatic treatment, 11 cases returned to normal, one case lost to follow-up, one case survived liver transplantation and 3 died. Conclusion: Moxifloxacin-induced liver damage can cause death, and medical staff should attach great importance to this serious adverse reaction of moxifloxacin.