目的探讨低钾血症致 QT 延长并发尖端扭转性室性心动过速(TDP)的救治方法。方法 22例低钾血症致 QT 延长并发 TDP 的患者,先后给予硫酸镁、利多卡因、异丙肾上腺素治疗,并同时进行补钾,观察治疗前后患者心率、QTc、血清钾的变化及 TDP 发作情况。结果应用硫酸镁、利多卡因疗效不佳,而异丙肾上腺素可有效终止 TDP 发作。前后比较,心率无显著差异,P>0.05,而 QTc 显著缩短,P<0.01,血清钾恢复正常,P<0.01。结论异丙肾上腺素能显著缩短 QT 间期,是终止继发性 QT 延长并发 TDP 的最有效药物,而补钾纠正病因是治疗的关键。 Objective To investigate the treatment of hypokalemia-induced QT prolonged torsades de pointes ventricular tachycardia (TDP). Methods Twenty-two hypokalaemia patients with QT prolongation and TDP were treated with magnesium sulfate, lidocaine and isoproterenol, and then potassium supplementation. The changes of heart rate, QTc, serum potassium and TDP were observed before and after treatment Attack situation. Results Magnesium sulfate, lidocaine ineffective, and isoproterenol can effectively terminate the onset of TDP. Before and after comparison, no significant difference in heart rate, P> 0.05, and QTc significantly shortened, P <0.01, serum potassium returned to normal, P <0.01. Conclusions Isoproterenol can significantly shorten the QT interval, which is the most effective drug for terminating secondary QT prolongation and concurrent TDP. The cause of potassium replacement is the key to treatment.