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目的探讨孕妇孕中晚期的25-羟维生素D 25OHD水平状况及其与血钙、磷、甲状旁腺激素(PTH)、空腹血糖、空腹真胰岛素、血脂、血压、孕前BMI的相关关系。方法研究对象为2006～2008年在北京协和医院就诊的正常孕妇83名,于孕24～28周取血,检测25OHD、PTH、血钙、磷、血糖、真胰岛素和血脂水平,并测量血压,计算孕前BMI。统计分析维生素D水平正常、不足和缺乏的情况,及维生素D水平与上述指标的相关性。结果孕中晚期维生素D水平缺乏的占50.6%,维生素D不足占45.8%,维生素D正常占3.6%。维生素D水平与孕前BMI、收缩压呈负相关(相关系数分别为r=-0.295,P=0.007和r=-0.275、P=0.012)。结论孕中晚期维生素D水平不足或缺乏是普遍现象,孕期应注意补充维生素D治疗。
Objective To investigate the level of 25-hydroxyvitamin D 25OHD in pregnant women in the second trimester of pregnancy and its relationship with serum calcium, phosphorus, parathyroid hormone (PTH), fasting blood glucose, fasting true insulin, blood lipids, blood pressure and pre-pregnancy BMI. Methods Totally 83 pregnant women were enrolled in the Peking Union Medical College Hospital from 2006 to 2008.Methods The blood samples were taken from 24 to 28 weeks of gestation and the levels of 25OHD, PTH, serum calcium, phosphorus, blood glucose, true insulin and blood lipid were measured. Calculate BMI before pregnancy. Statistical analysis of vitamin D levels were normal, inadequate and lack of circumstances, and vitamin D levels and the above indicators. Results In the second and third trimester of pregnancy, the deficiency of vitamin D accounted for 50.6%, the deficiency of vitamin D was 45.8%, and the proportion of vitamin D was 3.6%. Vitamin D levels were negatively correlated with pre-pregnancy BMI and systolic blood pressure (r = -0.295, P = 0.007 and r = -0.275, respectively, P = 0.012). Conclusion Insufficient or lack of vitamin D in the second trimester of pregnancy is a common phenomenon. During pregnancy, vitamin D supplementation should be considered.