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[目的]分析病毒和宿主因素及治疗过程中不同病毒学应答模式对慢性丙型肝炎干扰素(IFN)治疗结局的影响,为临床干扰素抗病毒治疗疗效预测及治疗方案选择提供依据。[方法]分析30例应用干扰素治疗的慢性丙型肝炎患者基因型、病毒载量、IFN种类、治疗过程中不同的病毒学应答模式以及年龄、性别、体重、肝脏脂肪变性等多种因素与干扰素疗效的关系。HCV基因分型应用直接测序法,HCVRNA载量采用荧光定量PCR法。[结果]持续应答(SVR)组和无应答(NR)组和患者的年龄、性别、体重无差异;NR组脂肪肝患者明显多于SVR组(χ2=5.662,P﹤0.05);HCVRNA载量两组无差异(SVR组6.32±0.828vsNR组6.08±0.892);基因型1b型患者的SVR率(35.7)低于2a型(67.7),Peg-干扰素治疗SVR率(67.7)高于普通干扰素(41.7)。SVR组RVR获得率达71.4,明显高于NR组(12.5);EVR的获得率两组均较低(28.6vs25),且差异无统计学意义。[结论]病毒和宿主因素中,年龄、性别、体重与干扰素疗效无关,肝脏脂肪变性、基因型1b型患者干扰素治疗SVR率较低。长效干扰素疗效高于普通干扰素。RVR的出现对SVR的获得有预测作用。
[Objective] To analyze the effect of virus and host factors and different patterns of virological response during treatment on the outcome of chronic hepatitis C virus (IFN) treatment and provide the basis for predicting the therapeutic effect of interferon antiviral therapy and the choice of treatment options. [Methods] The genotypes, viral load, IFN types, different patterns of virological response and the age, sex, body weight and hepatic steatosis of 30 chronic hepatitis C patients treated with interferon were analyzed. [Methods] Interferon curative effect of the relationship. HCV genotyping using direct sequencing, HCV RNA load using quantitative PCR. [Results] There was no difference in age, sex and weight between patients in continuous-response (SVR) group and non-responsive (NR) group and in patients with NRF. The incidence of fatty liver in NR group was significantly higher than that in SVR group (χ2 = 5.662, The SVR rate was lower in patients with genotype 1b than in patients with genotype 1b (67.7% vs 67.7% vs 67.7%, P <0.05) Prime (41.7). The rate of obtaining RVR in SVR group was 71.4, which was significantly higher than that in NR group (12.5). The EVR acquisition rate was lower in both groups (28.6 vs 25), with no significant difference. [Conclusion] Among the virus and host factors, the age, sex, body weight and the efficacy of interferon have nothing to do, liver steatosis, genotype 1b patients with interferon therapy SVR rate is low. Long-acting interferon efficacy than ordinary interferon. The occurrence of RVR has a predictive effect on the acquisition of SVR.