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目的研究有机磷农药中毒洗胃后立即灌注大剂量硫糖铝混悬液预防上消化道出血的疗效。方法83例有机磷农药重度中毒患者随机分为2组,对照组40例在彻底洗胃后予西米替丁0．4静推,2次/ d,口服或鼻饲硫糖铝1．0/次,4次/d,连服5 d。治疗组在每次洗胃后胃管内立即注入硫糖铝3．0(研碎+温开水80ml),并同时辅以西米替丁、硫糖铝的常规治疗(同对照组)。结果治疗组在隐性出血、显性出血和住院时间上明显低于对照组(P＜0．05),但死亡率差异无显著性(P＞0．05)。结论有机磷农药中毒洗胃后立即灌注大剂量硫糖铝混悬液对预防上消化道出血及缩短住院时间上有明显疗效。
Objective To study the efficacy of organophosphorus pesticide poisoning immediately after gastric lavage with high dose sucralfate suspension to prevent upper gastrointestinal bleeding. Methods Eighty-three patients with organophosphate pesticide severe poisoning were randomly divided into two groups. In the control group, 40 patients were given cimetidine 0.4 intravenously after a complete gastric lavage, 2 times / d, oral or nasal feeding sucralfate 1.0 / Times, 4 times / d, and even served 5 d. In the treatment group, sucralfate 3.0 (milled + warm water 80ml) was infused immediately after gastric lavage. At the same time, cimetidine and sucralfate were given routinely (same as the control group). Results In the treatment group, the incidences of occult hemorrhage, overt bleeding and hospital stay were significantly lower than those of the control group (P <0.05). However, there was no significant difference in mortality between the two groups (P> 0.05). Conclusion The organophosphorus pesticide poisoning immediately after gastric lavage infusion of high-dose sucralfate suspension on the prevention of upper gastrointestinal bleeding and shorten the length of stay have a significant effect.