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目的探讨婴幼儿肺炎支原体肺炎(MPP)患儿临床症状与T细胞亚群改变之间的关系。方法 63例MPP患儿分为喘息性肺炎35例(A组)与非喘息性肺炎28例(B组);应用流式细胞术检测患儿急性期外周血T细胞亚群表达;其结果与41例健康儿童(C组)对照。结果 A组CD3+CD4+表达明显低于B、C组(32.56±5.13vs.39.84±5.61、36.01±6.06);A组CD4+/CD8+比率也明显低于B、C组(1.45±0.35vs.2.08±0.42、1.63±0.56)(P<0.05),而CD3-CD19+表达明显升高(29.40±6.56vs.22.24±5.74、20.30±5.29)(P<0.05)。结论婴幼儿MPP中喘息性肺炎存在淋巴细胞亚群免疫功能降低和B淋巴细胞功能亢进,与支气管哮喘之间可能存在共同的发病机制。
Objective To investigate the relationship between the clinical symptoms and the changes of T cell subsets in infants with mycoplasma pneumoniae pneumonia (MPP). Methods Sixty-three children with MPP were divided into 35 cases of asthmatic pneumonia (group A) and 28 cases of non-wheezing pneumonia (group B). The expression of T lymphocyte subsets in peripheral blood was detected by flow cytometry 41 healthy children (C group) control. Results The expression of CD3 + CD4 + in group A was significantly lower than that in group B and C (32.56 ± 5.13 vs.39.84 ± 5.61, 36.01 ± 6.06). The ratio of CD4 + / CD8 + in group A was significantly lower than that in group B and C (1.45 ± 0.35 vs. 2.08 ± 0.42,1.63 ± 0.56) (P <0.05), while the expression of CD3-CD19 + increased significantly (29.40 ± 6.56 vs.22.24 ± 5.74 and 20.30 ± 5.29) (P <0.05). Conclusions Infants and young children with asthmatic pneumonia in MPP have decreased lymphocyte subsets immunity and hyperactivity of B lymphocytes, and may have a common pathogenesis with bronchial asthma.