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目的探讨肿瘤相关抗原CA15-3水平和阳性率与乳腺癌复发、转移等预后因素的关系。方法选择80例不同病理类型乳腺癌患者作前瞻性研究,并采用免疫放射分析法(IRMA)进行检测CA15-3水平。结果不同淋巴结及远处癌转移状况、不同的乳腺癌患者血清CA15-3水平及其阳性率差异显著(P<0.05)。对患者术后随访期间CA15-3动态观察发现,术后较术前有所下降,局部或对侧复发者较无瘤生存者明显升高,对手术治疗的彻底性也有一定指导意义。结论对乳腺癌患者尤其是在术后定期检测血清CA15-3水平变化,可作为监测复发和转移等的一项有价值的指标。
Objective To investigate the relationship between the level of CA15-3 and the positive rate of tumor-associated antigen (CA15-3) and the prognosis of breast cancer such as recurrence and metastasis. Methods Eighty patients with different pathological types of breast cancer were selected for prospective study. The level of CA15-3 was detected by immunohistochemical method (IRMA). Results There were significant differences in serum CA15-3 levels and positive rates among different breast cancer patients (P <0.05) with different lymph nodes and distant metastasis. The dynamic observation of CA15-3 during follow-up of patients showed that postoperative decreased compared with preoperative, local or contralateral recurrence was significantly higher than non-survivors, the thoroughness of surgical treatment also has some guiding significance. Conclusions The serum levels of CA15-3 in breast cancer patients, especially after regular follow-up, can be used as a valuable indicator to monitor recurrence and metastasis.