论文部分内容阅读
目的 :观察糖尿病肾病患者不同病理时期血中胰岛素样生长因子 I(IGF I)、尿中表皮生长因子 (EGF)含量的变化 ,及其与糖化血红蛋白A1c(GHbA1c)、生长激素 (GH)、病程的关系。方法 :IGF I、EGF、GH测定采用放射免疫法 ,GHbA1c测定采用微柱法。结果 :早期糖尿病肾病者体内IGF I、EGF水平较正常人升高 ;晚期糖尿病肾病者IGF I、EGF水平较正常人明显下降。结论 :IGF I、EGF在糖尿病及糖尿病肾病的发生发展中起重要作用
OBJECTIVE: To observe the changes of blood levels of insulin-like growth factor-I (IGF-I) and urine epidermal growth factor (EGF) in patients with diabetic nephropathy at different pathological stages and the relationship with the changes of GHbA1c, GH, Relationship. Methods: Radioimmunoassay was used to determine IGF I, EGF and GH, and microcolumn method was used to determine GHbA1c. Results: The levels of IGF I and EGF in patients with early diabetic nephropathy were higher than those in normal people. The levels of IGF I and EGF in patients with advanced diabetic nephropathy were significantly lower than those in normal controls. Conclusion: IGF I and EGF play an important role in the development of diabetes and diabetic nephropathy