论文部分内容阅读
目的石菖蒲水煎液和浓缩液的药物成分。方法选取石菖蒲放置在陶器中模拟汤剂临床煎法煎煮2次并浓缩,采用气相色谱联合质谱分析的方法将取出的6批次水煎液和浓缩液进行分析和对比。结果 2次石菖蒲水煎液中主要成分为2,3-二氢-3,5-二羟基-6-甲基-4H-吡喃-4-酮、β-细辛醚、5-羟甲基糠醛、α-细辛醚及细辛酮,2次石菖蒲水煎液中含量较高的为β-细辛醚,含量较低的为细辛酮。石菖蒲浓缩液中2,3-二氢-3,5-二羟基-6-甲基-4H-吡喃-4-酮含量为(11.46±3.38)%、β-细辛醚含量为(5.06±2.06)%、5-羟甲基糠醛含量为(31.16±5.62)%、α-细辛醚含量为(5.08±2.13)%,细辛酮含量为(2.27±1.44)%,其中含量最高的为5-羟甲基糠醛。结论石菖蒲临床疗效的物质基础是多样的,不仅与挥发油成分有关,而且还含有较高含量的水溶性成分,在研制新药的过程中,应当重视供药理实验采用的浓缩液与临床实际应用的汤剂的不同之处。
Purpose Shichangpu decoction and concentrate of the drug composition. Methods Shichangpu placed in pottery simulating decoction decoction clinical decoction 2 times and concentrated by gas chromatography combined with mass spectrometry analysis of the six batches of decoction and concentrate removed for analysis and comparison. Results The main constituents of the 2 times Acorus gramineus decoction were 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one, β-asarone, Furfural, α-asarone, and octanone, and the content of β-asarone in the 2 times Acorus calamus decoction was higher. The content of 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one in Shichangpu concentrate was (11.46 ± 3.38)%, ± 2.06)%, the content of 5-hydroxymethylfurfural was (31.16 ± 5.62)%, the content of α-asarone was (5.08 ± 2.13)% and the content of octanone was (2.27 ± 1.44)%, 5-hydroxymethyl furfural. Conclusion The clinical basis of the clinical efficacy of Acorus gramineus is diverse, not only related to the volatile oil components, but also contains a high content of water-soluble components. In the process of developing new drugs, attention should be paid to the concentrate used in pharmacological experiments and clinical practical application Differences in decoction.