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目的 :探讨肺癌发病机制及早期监测指标 ,为多环芳烃作业人员劳动保护提供科学依据。方法 :对 5 1名多环芳烃类混合物接触者 (接触组 ) ,18例非肺癌患者 ,2 5例肺癌患者和 31名健康人员的血清脂质结合唾液酸(LSA)、谷胱甘肽S 转移酶 (GST)活性、超氧化物歧化酶同工酶 (SOD ,MnSOD和CuMnSOD)和T淋巴细胞亚群 (T3,T4,T8及T4/T8)进行测定。结果 :接触组、肺癌组和非肺癌组LSA均显著高于对照组 (P <0 .0 1)。接触组、非肺癌组和肺癌组GST显著高于对照组 (P <0 .0 5 )。肺癌组SOD显著高于非肺癌组 (P <0 .0 5 )。接触组、肺癌组和非肺癌组T3均显著低于对照组 (P <0 .0 5 ) ,接触组T3显著高于非肺癌组和肺癌组 (P <0 .0 5 ) ;接触组、非肺癌组和肺癌组T4均显著低于对照组 (P <0 .0 5 ) ,接触组T4显著高于非肺癌组 (P <0 .0 5 ) ;非肺癌组T4/T8显著低于对照组 (P <0 .0 1) ,接触组T4/T8显著高于非肺癌组 (P <0 .0 5 )。结论 :多环芳烃接触者生物膜出现了损伤性改变 ,免疫功能受到抑制。
Objective: To investigate the pathogenesis of lung cancer and early monitoring indicators to provide a scientific basis for labor protection of PAHs workers. Methods: Serum lipids-associated sialic acid (LSA), glutathione S (superscript +) and glutathione S-reactive protein (GST) activity, superoxide dismutase isoenzyme (SOD, MnSOD and CuMnSOD) and T lymphocyte subsets (T3, T4, T8 and T4 / T8) were measured. Results: LSA in contact group, lung cancer group and non-lung cancer group were significantly higher than those in control group (P <0.01). GST in contact group, non-lung cancer group and lung cancer group was significantly higher than that in control group (P <0.05). SOD in lung cancer group was significantly higher than that in non-lung cancer group (P <0.05). The contact group, lung cancer group and non-lung cancer group T3 were significantly lower than the control group (P <0 05), contact group T3 was significantly higher than non-lung cancer group and lung cancer group (P <0 05); contact group T4 in lung cancer group and lung cancer group were significantly lower than those in control group (P <0.05), T4 in contact group was significantly higher than that in non-lung cancer group (P <0.05), T4 / T8 in non-lung cancer group was significantly lower than that in control group (P <0.01), and T4 / T8 in contact group was significantly higher than that in non-lung cancer group (P <0.05). CONCLUSION: The biofilms of PAHs exposed to tetanic injury have been impaired and immune function is inhibited.