慢性乙型肝炎是一个全球性的重大健康问题,病毒复制活跃的患者在5年内易发生肝硬化,对于肝硬化患者,病情可发生急性加重、疾病进展,肝细胞癌的发生率也明显升高,由于存在这些并发症,患者的5年生存率明显降低。研究显示,发生肝硬化并发症的主要决定因素为病毒负荷[1],持续乙型肝 Chronic hepatitis B is a major global health problem. Patients with active viral replication are susceptible to cirrhosis within 5 years. In cirrhotic patients, the disease may be exacerbated, the disease progresses, and the incidence of hepatocellular carcinoma is also significantly increased Due to these complications, the patient’s 5-year survival rate was significantly reduced. Studies have shown that the main determinants of the occurrence of cirrhosis complications are viral load [1], persistent hepatitis B