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采用ＦⅧ相关抗原及增殖细胞核抗原（ＰＣＮＡ）抗体对５０例乳腺浸润性导管癌进行免疫组化研究。结果：癌组织内微血管密度（ＭＶＣ）与肿瘤大小，组织学分级及腋窝淋巴结转移均无相关性（Ｐ＜０．０５）。ＰＣＮＡ表达水平虽与肿瘤大小无关（Ｐ＞０．０５），但乳腺癌Ⅱ、Ⅲ级者其ＰＣＮＡ表达水平明显高于Ｉ级，并有显著差异（Ｐ＜０．０５）：腋窝淋巴结转移组其ＰＣＮＡ表达水平明显高于无淋巴结转移组，且有显著差异（Ｐ＜０．０５）。结果提示乳腺癌组织内微血管密度对评估其预后实用价值不大。ＰＣＮＡ的表达水平与乳腺癌组织学分级及腋窝淋巴结转移均有密切关系，它可作为反映乳腺癌侵袭能力的一项重要指标，对评估乳腺癌的转移和预后有辅助意义。
Fifty cases of invasive ductal carcinoma of the breast were studied by immunohistochemistry using FVIII-associated antigen and proliferating cell nuclear antigen (PCNA) antibody. RESULTS: There was no correlation between microvessel density (MVC), tumor size, histological grade, and axillary lymph node metastasis (P < 0.05). Although the expression level of PCNA was not related to tumor size (P>0.05), the PCNA expression level of breast cancer grades II and III was significantly higher than that of grade I, with significant difference (P<0.05): axillary lymph node metastasis group The expression level of PCNA was significantly higher than that without lymph node metastasis, and there was a significant difference (P<0.05). The results suggest that microvessel density in breast cancer tissue is of little practical value in assessing its prognosis. The expression level of PCNA is closely related to the histological grade and axillary lymph node metastasis of breast cancer. It can be used as an important index to reflect the invasive ability of breast cancer, and it is helpful to evaluate the metastasis and prognosis of breast cancer.