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目的 :探讨一氧化氮 (nitric oxide,NO)、一氧化氮合酶 (nitric oxide synthase,NOS)、超氧化物歧化酶 (superoxidedismutase,SOD)及氧自由基在分泌性中耳炎 (secretory otitis media,SOM)发病机制中的作用。方法 :对实验性 SOM和SOM患者中耳积液和血清中 NO、NOS、SOD及氧自由基进行检测 ,并比较单纯应用抗生素与 NO合成抑制剂 +抗氧化剂 +抗生素治疗 SOM后血清中各指标的变化情况。结果 :实验性 SOM和 SOM患者血清中 NO、NOS、SOD、MDA含量均明显高于正常对照组。鼓室积液中 NO、NOS、SOD、MDA含量均明显高于血清中含量。 NO合成抑制剂 +抗氧化剂 +抗生素治疗SOM后血清 NO、NOS、SOD、MDA含量明显低于单纯应用抗生素组 ,差别有统计学意义。结论 :NO、NOS、SOD及氧自由基在分泌性中耳炎发病和转归中起重要作用 ,N-硝基 - L -精氨酸甲酯 (L - NAME)、维生素 C、维生素 E及 SOD对 SOM的治疗有效。
Objective: To investigate the effects of nitric oxide (NO), nitric oxide synthase (NOS), superoxide dismutase (SOD) and oxygen free radicals on secretory otitis media (SOM) ) Pathogenesis in the role. Methods: The levels of NO, NOS, SOD and oxygen free radicals in middle ear effusion and serum of patients with SOM and SOM were measured. The levels of serum SOM in serum after simple antibiotics combined with inhibitors of NO synthesis + antioxidants + antibiotics Changes in the situation. Results: The serum levels of NO, NOS, SOD and MDA in experimental SOM and SOM patients were significantly higher than those in normal control group. The contents of NO, NOS, SOD and MDA in tympanic fluid were significantly higher than those in serum. The contents of NO, NOS, SOD and MDA of NO synthesis inhibitors + antioxidants + antibiotics after treatment of SOM were significantly lower than those of antibiotics alone group, the difference was statistically significant. Conclusion: NO, NOS, SOD and oxygen free radicals play an important role in the pathogenesis and prognosis of secretory otitis media. The effects of N - nitro - L - arginine methyl ester, vitamin C, vitamin E and SOD SOM treatment effective.