论文部分内容阅读
目的：研究胃癌组织中生长抑素的表达及与淋巴结转移、预后、ＤＮＡ倍体的关系。方法：应用免疫组化及图像分析技术对１４０例各组织学类型胃癌中生长抑素（ＳＳ）的表达及ＤＮＡ倍体进行观察，并对其中１２７例患者进行随访。结果：３６例胃癌中检出ＳＳ阳性细胞（２５．７％）。ＳＳ的表达与分布特点、胃癌组织学类型、分化及淋巴结转移无明显关系，但与预后有明显关系，ＳＳ阳性胃癌组预后较好，较ＳＳ阴性胃癌组生存期长（Ｐ＜０．０１）。ＤＮＡ图像分析显示，与ＳＳ阴性胃癌组相比，ＳＳ阳性胃癌组的３～４Ｃ与５Ｃ细胞所占比例较大，＞５Ｃ细胞所占比例较小。结论：ＳＳ作为抑制因子不仅可抑制胃癌细胞的生长，而且含有ＳＳ细胞的胃癌患者生存期长，预后较好。推测胃癌中分泌的ＳＳ和其自身膜表面受体结合，抑制自身生长
Objective: To study the expression of somatostatin in gastric cancer and its relationship with lymph node metastasis, prognosis and DNA ploidy. METHODS: Immunohistochemical and image analysis techniques were used to observe the expression of somatostatin (SS) and DNA ploidy in 140 cases of histological types of gastric cancer, and 127 of them were followed up. Results: SS positive cells were detected in 36 cases of gastric cancer (25.7%). There was no significant relationship between the expression and distribution characteristics of SS, histological type, differentiation and lymph node metastasis, but it had a significant relationship with prognosis. SS positive gastric cancer group had better prognosis and longer survival time than SS negative gastric cancer group (P<0.01). . DNA image analysis showed that 3 to 4C and 5C cells in the SS positive gastric cancer group accounted for a larger proportion of the SS negative gastric cancer group, and the proportion of >5C cells was smaller. Conclusion: SS as an inhibitory factor not only inhibits the growth of gastric cancer cells, but also has a long survival period and a good prognosis in gastric cancer patients with SS cells. Presumably, SS secreted in gastric cancer binds to its own membrane surface receptor and inhibits its own growth.