论文部分内容阅读
目的:探讨一贯煎合丹参抗慢性肝纤维化的作用机制。方法:将50只雄性SD大鼠随机分为空白对照组、模型组、一贯煎组、丹参组、一贯煎合丹参组,每组10只。除空白对照组外,其余各组予CCL4行慢性肝损伤肝纤维化模型制备,同时予相应药物灌胃,空白组灌胃蒸馏水。8周后观察各组大鼠肝组织TGF-β1及α-SMA表达情况。结果:与模型组比较,一贯煎组、丹参组、一贯煎合丹参组大鼠肝组织TGF-β1及α-SMA的表达均有提高(P<0.05),一贯煎合丹参组提高更显著(P<0.05)。结论:一贯煎合丹参具有叠加抗肝纤维化作用,其机制可能与抑制肝组织TGF-β1及α-SMA的表达有关。
Objective: To investigate the mechanism of anti-chronic liver fibrosis induced by Salvia miltiorrhiza. Methods: Fifty male Sprague-Dawley rats were randomly divided into blank control group, model group, Guanjian decoction group, Salvia miltiorrhiza group and Salvia miltiorrhiza group, 10 in each group. In addition to the blank control group, the remaining groups were given CCL4 chronic liver injury model of liver fibrosis, at the same time to the corresponding drug gavage, blank group fed with distilled water. After 8 weeks, the expression of TGF-β1 and α-SMA in each group were observed. Results: Compared with the model group, the expressions of TGF-β1 and α-SMA in the group of Yi Guan Decoction, Salvia Miltiorrhiza, and Danshen Salviae Miltiorrhizae were all significantly increased (P <0.05) P <0.05). Conclusion: Salvia miltiorrhiza has the effect of anti-hepatic fibrosis. Its mechanism may be related to inhibiting the expression of TGF-β1 and α-SMA in liver tissue.