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目的探讨者年黄斑变性的病变发展特征及演变过程并且进一步找出对老年黄斑变性进行临床监控的可行性指标。方法使用眼底荧光血管造影、眼底彩色照相、对比敏感度、视力和视野检查，对23例（46眼）老年黄斑变性患者进行了6～25个月（平均20．1个月）随访检测。结果46眼视力平均下降0．12，对比敏感度与Amsler方格检查的变化比较普遍，19．5％的眼底黄斑病变发展较明显。结论老年黄斑变性的病灶发展与视功能变化相一致，其中对比敏感度和Amsler方格表检查更能反映老年黄斑变性的病变发展过程。
Objective To investigate the characteristics and evolution of lesions in patients with age-related macular degeneration and to further identify the feasibility of clinical monitoring of age-related macular degeneration. Methods 23 eyes (46 eyes) with age-related macular degeneration were followed up for 6 to 25 months (average 20.1 months) using fundus fluorescein angiography, fundus color photography, contrast sensitivity, visual acuity and visual field examination. Results The average visual acuity of 46 eyes decreased by 0.12. Contrast sensitivity was more common with Amsler square test, and 19.5% of eyes had macular degeneration more obvious. Conclusion The development of age-related macular degeneration is consistent with the change of visual function. Contrast sensitivity and Amsler grid test can reflect the development of age-related macular degeneration.