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目的检测了ｎｍ２３－Ｈ１基因产物ｎｍ２３－Ｈ１蛋白在７０例大肠癌中的表达，就其临床意义进行探讨。方法免疫组化ＬＳＡＢ方法。结果ｎｍ２３－Ｈ１蛋白在大肠癌中有较高的表达，阳性率为４４．３％；分化程度高者阳性率高于分化程度低者，有淋巴结转移的表达阳性率（２３．１％）明显低于无转移者（７０．９％），表达阳性率随分期的进展逐渐下降，与预后呈正相关。ｎｍ２３－Ｈ１蛋白在大肠癌的分化发展中起一定的作用。结论检测ｎｍ２３－Ｈ１蛋白的表达可成为评价大肠癌患者预后的指标
Objective To detect the expression of nm23-H1 gene product nm23-H1 protein in 70 cases of colorectal cancer and discuss its clinical significance. Methods Immunohistochemical LSAB method. Results The nm23-H1 protein was highly expressed in colorectal cancer, with a positive rate of 44.3%. The positive rate of high differentiation was higher than that of low differentiation, and the positive rate of lymph node metastasis was obviously (23.1%). Compared with those without metastasis (70.9%), the positive rate of expression gradually decreased with the progression of the stage, which was positively correlated with the prognosis. The nm23-H1 protein plays a role in the differentiation and development of colorectal cancer. Conclusion Detecting the expression of nm23-H1 protein may be an indicator to evaluate the prognosis of colorectal cancer patients