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目的探讨骨内恶性血管球瘤的临床病理特征。方法对1例胸椎恶性血管球瘤的临床表现、影像学、组织学特征、免疫组化结果进行分析,并文献复习。结果患者男性,60岁。胸背部疼痛2年。术前MRI提示胸8椎体病变。镜下肿物呈结节状,由玻璃样变性的纤维结缔组织分隔,肿瘤组织呈血窦样结构,血窦衬覆内皮细胞,窦间为数层肿瘤细胞,瘤细胞上皮样,胞界较清晰,胞质淡染,胞核大小不等,核分裂象少见。免疫组化示肿瘤细胞vimentin和SMA(+)。结论椎骨内恶性血管球瘤罕见,低度恶性,具有独特的病理形态学特征。
Objective To investigate the clinicopathological features of intraosseous malignant glioma. Methods The clinical manifestations, imaging features, histological features and immunohistochemical results of 1 thoracic malignant glioma were analyzed and reviewed. Results The patient was male, 60 years old. Chest and back pain for 2 years. Preoperative MRI tips chest 8 vertebral lesions. Microscopically, the tumor was nodular and was separated by connective tissue with degenerative fibrosis. The tumor tissue showed a sinusoid-like structure. The endothelial cells were covered by blood sinus, and several tumor cells were found in the sinus. Epithelial tumor cells had a clear cytoplasm , Light cytoplasm, nucleus size, rare mitosis. Immunohistochemistry showed that tumor cells vimentin and SMA (+). Conclusion Vertebral malignant glomus is rare and low malignant and has unique histopathological features.