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目的了解老年患者泌尿道感染病原菌的分布和耐药状况。方法对312例泌尿道感染的老年患者分离的406株病原菌进行常规细菌培养,用K-B法进行药敏分析。结果老年泌尿道感染患者的病原菌以革兰阴性杆菌为主,占67.0%,主要有大肠埃希菌、变形菌属、肺炎克雷伯菌、阴沟肠杆菌、铜绿假单胞菌、鲍氏不动杆菌;革兰阳性球菌占29.1%,主要有屎肠球菌、粪肠球菌、金黄色葡萄球菌、凝固酶阴性葡萄球菌;同时还检出白色假丝酵母菌16株(4.0%);药敏结果显示,革兰阴性杆菌对亚胺培南、头孢哌酮/舒巴坦、阿米卡星较为敏感,革兰阳性球菌对万古霉素均敏感。结论老年患者泌尿道感染的病原菌耐药性严重,应定期监测病原菌的耐药趋势,以指导临床医生合理应用抗菌药物。
Objective To understand the distribution and drug resistance of pathogens in urinary tract infection in elderly patients. Methods Three hundred and sixty-six pathogenic bacteria isolated from elderly patients with urinary tract infection were routinely cultured and K-B method was used for drug susceptibility analysis. Results The main pathogens of elderly urinary tract infection were Gram-negative bacilli, accounting for 67.0%, mainly including Escherichia coli, Proteus, Klebsiella pneumoniae, Enterobacter cloacae, Pseudomonas aeruginosa, Acinetobacter; Gram-positive cocci accounted for 29.1%, mainly Enterococcus faecalis, Enterococcus faecalis, Staphylococcus aureus, coagulase-negative Staphylococcus aureus; also detected 16 strains of Candida albicans (4.0%); The results showed that Gram-negative bacilli were more sensitive to imipenem, cefoperazone / sulbactam and amikacin. Gram-positive cocci were sensitive to vancomycin. Conclusion The pathogens of urinary tract infection in elderly patients are seriously drug-resistant. The tendency of drug-resistant pathogens should be regularly monitored to guide clinicians in rational use of antimicrobial agents.