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鹿茸多肽(Pilose antler peptide,PAP)10和20mg·kg~(-1)ip对各种急慢性炎症具有明显的抑制作用。PAP可使大鼠肾上腺中的抗坏血酸和胆固醇含量降低,并使血清皮质醇含量明显升高;用地塞米松阻断垂体后,上述作用仍然存在。于去肾上腺大鼠PAP仍不失其抗炎作用。可见,PAP的抗炎作用不完全依赖于垂体—肾上腺皮质系统。
Pilose antler peptide (PAP) 10 and 20 mg·kg -1 ip had significant inhibitory effects on various acute and chronic inflammations. PAP can reduce the content of ascorbic acid and cholesterol in the adrenal gland of rats, and increase the serum cortisol content significantly; after the pituitary is blocked with dexamethasone, the above-mentioned effects still exist. PAP in the adrenal gland still retains its anti-inflammatory effects. It can be seen that the anti-inflammatory effects of PAP are not completely dependent on the pituitary-adrenocortical system.