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将我院2014—2016年收治的尘肺合并慢性阻塞性肺疾病急性加重期(AECOPD)的62例患者,随机分为观察组和对照组各31例。对照组采取常规治疗;观察组在常规治疗的基础上加用硫酸特布他林雾化吸入联合机械排痰治疗,10d为一个疗程;比较两组患者的临床症状(咳嗽、咳痰量、喘息)、体征(肺部痰鸣音)、血气分析[动脉血氧分压(PaO_2)、二氧化碳分压(PaCO_2)、动脉血氧饱和度(SaO_2)]、肺功能[第1秒最大呼气容积(FEV1.0)、最高呼气流量(PEF)]等指标变化。结果显示,观察组总有效率高于对照组,且观察组患者PaO_2、PaCO_2、SaO_2、FEV1.0、PEF值明显升高,各项指标优于对照组,差异有统计学意义(P<0.05)。提示硫酸特布他林雾化吸入联合机械排痰治疗尘肺合并AECOPD疗效显著。
Sixty-two patients with pneumoconiosis and acute exacerbation of chronic obstructive pulmonary disease (AECOPD) admitted from 2014 to 2016 in our hospital were randomly divided into observation group and control group, with 31 cases in each group. The control group was given routine treatment. The observation group was treated with inhalation of terbutaline sulphate combined with mechanical exhaust and sputum aspiration for 10 days on the basis of routine treatment. The clinical symptoms (cough, sputum volume, wheezing) ), Signs (pulmonary phlegm), blood gas analysis (PaO_2, PaCO_2, SaO_2), pulmonary function [1st second maximum expiratory volume (FEV1.0), maximum expiratory flow (PEF)] and other indicators of change. The results showed that the total effective rate in the observation group was higher than that in the control group, and the PaO_2, PaCO_2, SaO_2, FEV1.0 and PEF values in the observation group were significantly higher than those in the control group (P <0.05) ). Tip Terbutaline sulfate inhalation combined mechanical exhaust sputum pneumoconiosis with AECOPD significant effect.