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目的探讨血清胸苷激酶1(TK1)与癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原72-4(CA72-4)、细胞角蛋白片段21-1(CYFRA21-1)、神经元烯醇化酶(NSE)等肿瘤标志物联合检测对肺癌诊断的价值。方法采用免疫印迹增强化学发光法检测49例肺癌患者(A组)、32例肺部良性疾病患者和29例健康体检者(B组)血清TK1、CEA、CA 125、CA72-4、CYFRA21-1、NSE的水平。结果 TK1对肺癌诊断的敏感度为77.55%,特异度为93.44%。以上6项指标联合检测的敏感度和准确度分别为88.24%和90.91%。结论联合检测血清TK1、CEA、CA 125、CA72-4、CYFRA21-1、NSE的水平在提高敏感度的同时,也提高了肺癌诊断的准确度。
Objective To investigate the relationship between serum TK1 and CEA, CA125, CA72-4, CYFRA21-1, , Neuron enolase (NSE) and other tumor markers in the diagnosis of lung cancer. Methods The serum levels of TK1, CEA, CA125, CA72-4 and CYFRA21-1 in 49 patients with lung cancer (A group), 32 patients with benign pulmonary disease and 29 healthy subjects (Group B) , NSE level. Results The sensitivity of TK1 to lung cancer diagnosis was 77.55% and the specificity was 93.44%. The sensitivity and accuracy of the combined detection of the above six indexes were 88.24% and 90.91% respectively. Conclusions The combined detection of serum TK1, CEA, CA125, CA72-4, CYFRA21-1 and NSE can improve the sensitivity of lung cancer diagnosis and improve the accuracy of diagnosis.