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目的 :比较头孢三嗪 (ceftriaxone)治疗下呼吸道感染每日 1g与 2 g不同用量的有效性和安全性。方法 :采用随机对照、多中心临床试验方法 ,治疗下呼吸道感染 10 2例。剂量用法 :头孢三嗪1.0g或 2 .0g ,qd ,静脉点滴 ,疗程均为 7天。 结果 :头孢三嗪 1g组和头孢三嗪 2 g组总有效率分别为84.6 %、94.0 % ,2组痰细菌培养阳性率分别为 6 4.0 %、6 1.5 % ,致病菌 β 内酰胺酶阳性率分别为44 .8% ,6 6 .7% ,细菌清除率均为 93 .8% ,2组不良反应率分别为 2 .0 %、3 .8% ,以上结果经统计学处理2组比较无差异 (P >0 .0 5 )。结论 :应用头孢三嗪治疗下呼吸道感染有效、安全、耐受性好 ;每日 1g与每日 2 g疗效及安全性相当 ;每日用药 1g可节省药费开支。
OBJECTIVE: To compare the efficacy and safety of ceftriaxone in the treatment of lower respiratory tract infections with daily doses of 1 g and 2 g. Methods: A randomized, multicenter clinical trial was conducted to treat 102 cases of lower respiratory tract infection. Dosage usage: Ceftriaxone 1.0g or 2.0g, qd, intravenous drip, treatment are 7 days. Results: The total effective rates of ceftriaxone 1 g and cefotaxime 2 g were 84.6% and 94.0% respectively. The positive rates of sputum bacterial culture in the two groups were respectively 6 4.0% and 6 1.5%, and the positive rates of β lactamase were The rates of bacterial clearance were 93.8%, respectively. The adverse reaction rates of 2 groups were 2.0% and 3.8% respectively. The above results were statistically compared between the two groups No difference (P> 0.05). Conclusion: Ceftriaxone is effective, safe and well-tolerated for lower respiratory tract infection. Daily 1g is equivalent to 2g daily in safety and safety. Daily medication 1g can save medical expenses.