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目的观察辛伐他汀对缺血性心脏病心力衰竭(心衰)患者的临床疗效。方法将68例缺血性心脏病慢性心衰患者随机分为2组,对照组(常规治疗组)服用β受体阻滞剂+血管紧张素转换酶抑制剂+利尿剂+洋地黄,治疗组在对照组治疗的基础上加服辛伐他汀(20mg/d),随访24周,治疗前后采用心功能NYHA分级,超声心动图检测左室舒张末期内径、左室收缩末期内径及左室射血分数,进行疗效观察。结果治疗24周后,治疗组心功能改善,左室内径缩小,左室射血分数明显提高(P<0.05),肝肾功能无异常。结论辛伐他汀佐治缺血性心脏病心力衰竭,有较好效果,且无明显不良反应,效果良好。
Objective To observe the clinical effect of simvastatin on patients with heart failure (heart failure) of ischemic heart disease. Methods Sixty-eight patients with chronic heart failure with ischemic heart disease were randomly divided into two groups, the control group (conventional treatment group) taking beta-blocker plus angiotensin converting enzyme inhibitor plus diuretic plus digitalis, and the treatment group On the basis of the control group, simvastatin (20mg / d) was given for 24 weeks. Before and after treatment, the NYHA classification was used. The left ventricular end-diastolic diameter, left ventricular end-systolic diameter and left ventricular ejection fraction Score, the efficacy of observation. Results After 24 weeks of treatment, the cardiac function of the treatment group was improved, the left ventricular diameter was reduced, the left ventricular ejection fraction was significantly increased (P <0.05), and the liver and kidney function were normal. Conclusion Simvastatin adjuvant heart failure of ischemic heart disease, with good results, and no significant adverse reactions, the effect is good.