目的报道了一种新近由三氧化二铁磁性原料研制成功的口服磁共振胃肠造影剂。方法按照新药研究的方法进行了毒理、代谢、动力学、体外试管及动物体内磁共振成像试验,并对其进行了效果分析。结果和结论这种造影剂易于接受,安全性好,成像浓度范围宽,性能稳定,成本低,有优良超顺磁性的阴性对比效果,为临床试验提供依据。 Objective To report an oral magnetic resonance gastrointestinal contrast agent successfully developed by magnetic material of ferric oxide. Methods Toxicology, metabolism, kinetics, in vitro tubes and magnetic resonance imaging of animals in vivo were studied in accordance with the methods of new drug research, and their effects were analyzed. RESULTS AND CONCLUSION This contrast agent is easy to accept, has good safety, wide range of imaging concentration, stable performance, low cost and good superparamagnetic negative contrast effect, providing the basis for clinical trials.