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目的 研究促胎肺成熟药物地塞米松、ＥＧＦ、ＴＲＨ对母、胎组织感染及妊娠结局的影响。方法 建立孕兔宫内感染模型，分别用地塞米松、ＥＧＦ、ＴＲＨ联合先锋霉素Ｖ治疗，通过光镜观察母、胎组织的感染程度，检查孕兔和胎仔的存亡情况。结果 地塞米松治疗组胎肺和胎盘的感染程度明显重于对照组和／或ＥＧＦ治疗组，子宫感染程度在各组之间无明显差异；地塞米松治疗组孕兔发生早产和胎儿死亡的数量明显多于ＥＧＦ治疗组，ＴＲＨ治疗组的胎儿早产和死亡率明显高于ＥＧＦ治疗组和对照组，母兔死亡仅见于ＴＲＨ组。结论 在宫内感染时，地塞米松治疗可加重母、胎组织感染，引起胎儿早产或死亡，ＴＲＨ也具有加速早产和导致母、胎死亡的副作用，而ＥＧＦ不加重感染，对妊娠结局的影响较好。
Objective To study the effects of dexamethasone, EGF and TRH, a kind of fetal growth-promoting drug, on maternal and fetal tissue infection and pregnancy outcome. Methods The model of intrauterine infection in rabbits was established and treated with dexamethasone, EGF and TRH combined with PGEX respectively. The infection degree of mother and fetus was observed with light microscope, and the survival of pregnant rabbits and fetuses were examined. Results The incidence of fetal lung and placenta in dexamethasone treatment group was significantly higher than that in control group and / or EGF treatment group, and there was no significant difference in uterine infection among the groups. Dexamethasone treatment group had premature birth and fetal death The number of preterm birth and mortality in TRH treatment group was significantly higher than that in EGF treatment group and control group. The death of females was only found in TRH group. Conclusion In the intrauterine infection, dexamethasone treatment can aggravate maternal and fetal tissue infections, premature birth or death of the fetus, TRH also has accelerated side effects of premature birth and lead to fetal death, while EGF does not aggravate infection, the impact on pregnancy outcome better.