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自身免疫性血小板减少性紫癜(AITP)的细胞免疫病理生理机制首次综述是在十年前。但那时针对自身血小板抗原的自身IgG抗体的产生机制很少有研究,直到1995年,一些研究小组提出T细胞异常可能是慢性AITP自身抗体产生的原因。随后越来越多的证据指出AITP中存在自体反应T细胞,促使B细胞分化并分泌抗血小板自身IgG抗体。 正常免疫与自身免疫 对外来抗原的体液免疫反应是由多种类型细胞及其分泌产物构成的复杂的生物学反应。首先抗原如细胞表面糖蛋白等与抗原递呈细胞(APC)作用。APC主要指MHC-Ⅱ+巨噬细胞、
The first review of the pathophysiology of cellular immunity in autoimmune thrombocytopenic purpura (AITP) was ten years earlier. However, there was little research on the mechanism of production of autoantibody against platelet antigens at that time. Until 1995, some research groups suggested that T cell abnormalities may be responsible for the production of chronic AITP autoantibodies. Subsequently there is growing evidence that autologous reactive T cells are present in AITP, which prompts B cells to differentiate and secrete anti-platelet autoantibody IgG. The humoral immune response to foreign antigens, both normal and autoimmune, is a complex biological response composed of many types of cells and their secreted products. First, antigens such as cell surface glycoproteins and antigen presenting cells (APC) role. APC mainly refers to MHC-Ⅱ macrophages,