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作者研究了11例(女3例,男8例)平均年龄7.1岁的先天性心脏病患儿对洋地黄毒甙(简称毒甙)的代谢动力学。患儿肝肾功能正常,术前无心律失常。在矫正的心脏直视手术后24～48小时一次给药。其中5例静注17.5～20微克/公斤,6例口服20微克/公斤的毒甙溶液。血清毒甙蛋白结合试验的血清取自31名2～10岁的健康儿童。用放免法测定血清和尿的药物浓度。结果:毒甙口服吸收迅速而完全,生物利用度达101％。儿童1.5～2小时(成人1小时)血清药物浓度到达峰值为23～50毫微克/毫升。静注组平均药物—时间曲线下面积(AUC0—∞)为4674毫微克/毫升·小时,口服组为4850毫微克/
The authors studied the pharmacokinetics of digitoxin in children with congenital heart disease (average age 7.1 years) in 11 patients (3 males and 8 females). Children with normal liver and kidney function, no arrhythmia before surgery. In the corrected heart surgery 24 to 48 hours after a single administration. Among them, 5 cases were intravenously injected with 17.5-20 μg / kg and 6 cases were given 20 μg / kg of toxic glycoside solution. The sera of serum toxin protein binding test were taken from 31 healthy children aged 2 to 10 years old. Serum and urine drug concentrations were measured by radioimmunoassay. Results: Oral glycosides absorbed quickly and completely, bioavailability of 101%. Children 1.5 to 2 hours (1 hour adult) serum drug concentration peak reached 23 to 50 ng / ml. The mean area under the drug-time curve (AUC0-∞) of the intravenous group was 4674 ng / mLhour and the oral group was 4850 ng /