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目的探讨磁共振弥散加权成像(DWI)技术在晚期宫颈癌患者放射治疗效果监测中的应用价值,为今后的诊疗工作提供参考。方法 50例行放射治疗的晚期宫颈癌患者作为观察组,同时选取同期50例非宫颈癌患者作为对照组,两组患者入院后均采用1.5T核磁共振扫描仪对其子宫颈进行横断面DWI(b=700 s/mm~2),检测两组宫颈组织的表观弥散系数(ADC),并于观察组化疗后再次对其宫颈组织与正常组织(臀大肌组织)进行DWI检测,并对各组的ADC水平进行对比分析。结果放疗前,观察组的ADC水平为(0.82±0.31)×10~(-3) mm~2/s,明显低于对照组的(1.78±0.12)×10~(-3) mm~2/s(P<0.05)。放疗后,观察组的ADC水平为(1.62±0.34)×10~(-3) mm~2/s,与放疗前比较明显提高(P<0.05);与对照组以及正常组织ADC比较仍较低,但差异无统计学意义(P>0.05)。结论 DWI技术在晚期宫颈癌患者放射治疗效果监测中具有良好的临床指导价值,可以为宫颈癌患者的治疗方案制定提供重要依据。
Objective To investigate the value of magnetic resonance diffusion-weighted imaging (DWI) in the monitoring of radiotherapy in patients with advanced cervical cancer and provide reference for the future diagnosis and treatment. Methods Fifty patients with advanced cervical cancer undergoing radiotherapy were selected as the observation group. Fifty patients with non-cervical cancer at the same period were selected as the control group. All the patients were admitted to the hospital with a 1.5T MRI scanner for cross-sectional DWI b = 700 s / mm ~ 2). The apparent diffusion coefficient (ADC) of cervical tissue in both groups was detected. DWI was performed again on the cervical tissue and normal tissue (gluteus maximus) in the observation group after chemotherapy, ADC levels in each group were compared. Results The level of ADC in the observation group was (0.82 ± 0.31) × 10 ~ (-3) mm ~ 2 / s before radiotherapy, which was significantly lower than that in the control group (1.78 ± 0.12 × 10 -3 mm 2 / s (P <0.05). After radiotherapy, the level of ADC in observation group was (1.62 ± 0.34) × 10 ~ (-3) mm ~ 2 / s, which was significantly higher than that before radiotherapy (P <0.05); ADC in observation group and normal tissue was still lower , But the difference was not statistically significant (P> 0.05). Conclusion DWI has a good clinical value in the monitoring of radiotherapy effect in patients with advanced cervical cancer and can provide an important basis for the treatment of patients with cervical cancer.