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目的观察丹参酮ⅡA磺酸钠注射液(STS)治疗晚期血吸虫病(晚血)临床效果。方法选择2012-011-2013-11入住东台市头灶中心卫生院的晚血患者50例,予以STS治疗10 d,治疗前、后进行门静脉内径、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、γ-谷氨酰转肽酶(γ-GT)、Ⅲ型前胶原肽、Ⅳ型胶原、层黏蛋白、透明质酸(HA)检测。结果治疗前血清学检测指标的均值除HA高于正常外,余均正常;指标异常患者数最高分别为γ-GT(26.0%)及HA(54.0%)。治疗后各项指标均值和指标异常患者数均有所下降,但HA的均值仍高于正常。门静脉内径由治前的(10.5±1.7)mm降至治后的(9.8±1.3)mm,改善明显。结论 STS对晚血病人的治疗具有一定的效果,适合于基层单位使用。
Objective To observe the clinical effect of tanshinone Ⅱ A sodium sulfonate injection (STS) on advanced schistosomiasis (late blood). Methods Selection 2012-011-2013-11 50 patients with late-blooded patients admitted to Dongtai Head Center Hospital were treated with STS for 10 days. Before and after treatment, the portal vein diameter, alanine aminotransferase, aspartate amino (Γ-GT), procollagen type Ⅲ, type Ⅳ collagen, laminin and HA. Results The mean serum serological parameters before treatment were all higher than those of normal ones. The highest number of abnormal patients was γ-GT (26.0%) and HA (54.0%), respectively. After treatment, the mean of all indexes and the number of abnormal patients decreased, but the mean value of HA was still higher than normal. The diameter of portal vein decreased from (10.5 ± 1.7) mm before treatment to (9.8 ± 1.3) mm after treatment, which improved obviously. Conclusion STS has a certain effect on the treatment of patients with late-blooded, suitable for the use of grass-roots units.