1例男性25岁低钾性周期性麻痹患者,因慢性乙型病毒性肝炎给予替比夫定600mg,1次/d。治疗10个月后患者出现恶心、呕吐,全身酸痛,尿量减少,尿色加深。停用替比夫定,改用拉米夫定,并给予对症、支持治疗,下肢肌肉酸痛仍明显,遂入院。诊断为横纹肌溶解,代谢性酸中毒,慢性乙型病毒性肝炎。停用拉米夫定,并行对症、支持治疗。症状加重,入院第9天因呼吸、循环衰竭死亡。 One male 25-year-old hypokalemic periodical paralysis patients were given telbivudine 600mg once daily for chronic hepatitis B virus. After 10 months of treatment, the patient developed nausea, vomiting, body aches, decreased urine output and deepened urine color. Disable telbivudine, switch to lamivudine, and give symptomatic, supportive treatment, lower extremity muscle soreness is still obvious, then admitted to hospital. Diagnosis of rhabdomyolysis, metabolic acidosis, chronic hepatitis B virus. Disable lamivudine, symptomatic symptomatic, supportive treatment. Symptoms worsened, on admission 9 days due to respiratory failure, circulatory failure.