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目的 用扶正解毒汤 (FJD)防治硫酸镍的生殖毒性作用。方法 硫酸镍 (NiSO4 )腹腔注射染毒 ,FJD灌胃防治 ,观察精子畸变和睾丸病理 ,并用原子吸收法测定睾丸组织中微量元素含量。结果 NiSO4 可使精子畸变率升高 ,睾丸组织出现病理改变 ,睾丸组织中Ni2 + 含量上升 ,Zn2 + 、Mg2 + 、Fe2 + 、Mn2 + 等含量下降。用FJD防治后 ,精子畸变率有所下降 ,睾丸病理改变明显减轻 ,睾丸组织中Ni2 + 含量下降 ,Zn2 + 、Mg2 + 、Fe2 + 、Mn2 + 等含量回升。结论 FJD对硫酸镍所致的生殖毒性有防治作用 ,其机理与调整睾丸组织中微量元素含量有关。
Objective To use Fuzheng Jiedu Decoction (FJD) to prevent the reproductive toxicity of nickel sulfate. Methods Intraperitoneal injection of nickel sulfate (NiSO4) and intragastric administration of FJD were used to observe the changes of sperm motility and testicular pathology. The content of trace elements in testis was determined by atomic absorption spectrometry. Results NiSO4 increased sperm aberration rate, pathological changes in testis tissue, increased contents of Ni2 +, decreased contents of Zn2 +, Mg2 +, Fe2 + and Mn2 + in testis tissue. After treated with FJD, the rate of sperm aberration decreased, the testicular pathological changes significantly reduced, the content of Ni2 + in testis decreased, and the contents of Zn2 +, Mg2 +, Fe2 + and Mn2 + increased. Conclusion FJD can prevent reproductive toxicity caused by nickel sulfate, and its mechanism is related to the regulation of trace elements in testis.