论文部分内容阅读
目的:检测上皮性卵巢癌中Survivin和p16蛋白的表达,探讨其临床意义。方法:应用免疫组化S-P法,检测53例上皮性卵巢癌中Survivin和p16蛋白的表达。结果:上皮性卵巢癌组织中Survivin阳性表达35例(66%),其表达与上皮性卵巢癌组织学分型无关(P>0.05),而与其分化程度、临床分期和淋巴结转移有关(P<0.05);p16蛋白阳性表达21例(39.6%),其表达与上皮性卵巢癌组织学分型、分化程度、临床分期有关(P<0.05),而与其淋巴结转移无关(P>0.05)。结论:Survivin、p16蛋白在卵巢癌的发生、发展中起着重要的作用,是临床判断卵巢癌病变程度及预测预后的重要参考指标。
Objective: To detect the expression of Survivin and p16 protein in epithelial ovarian cancer and to explore its clinical significance. Methods: The expressions of Survivin and p16 in 53 cases of epithelial ovarian cancer were detected by immunohistochemical S-P method. Results: The positive expression of Survivin in epithelial ovarian cancer was 35 cases (66%). The expression of Survivin was not related with the histological type of epithelial ovarian cancer (P> 0.05), but correlated with the degree of differentiation, clinical stage and lymph node metastasis ). The positive expression of p16 protein was found in 21 cases (39.6%). The expression of p16 protein was correlated with histological type, differentiation degree and clinical stage of epithelial ovarian cancer (P <0.05), but not with lymph node metastasis (P> 0.05). CONCLUSIONS: Survivin and p16 proteins play an important role in the development and progression of ovarian cancer. It is an important reference for clinical judgment of the degree of ovarian cancer and prognosis.