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目的:研究中医辨证疗法联合甲疏咪唑治疗甲状腺功能亢进的临床效果及对后期复发的影响。方法:将我院64例甲状腺功能亢进症患者以随机数字表法分为观察、对照两组,均行西药(甲硫咪唑)治疗,观察组另予中药辨证治疗,比较两组临床疗效、甲状腺功能指标[促甲状腺素受体抗体(TRAB)、促甲状腺激素(TSH)、总三碘甲状腺激素(TT3)、总四碘甲状腺激素(TT4)、游离三碘甲状腺激素(FT3)、游离四碘甲状腺激素(FT4)]及随访3年内复发率。结果:1临床疗效:观察组治疗总有效率75.0%VS 46.9%,显著较高(P<0.05);2甲状腺功能:治疗后观察组TRAB(2.87±1.54)IU/ml VS(4.61±2.97)IU/ml、TT3(1.32±0.44)noml/LVS(3.51±0.66)noml/L、TT4(98.14±31.90)noml/LVS(114.30±29.46)noml/L、FT3(7.16±1.87)poml/L VS(9.11±2.14)poml/L、FT4(22.94±5.31)poml/L VS(28.16±6.24)poml/L,均低于对照组(P<0.05),TSH(0.82±0.47)μIU/ml VS(0.49±0.37)μIU/ml显著高于对照组(P<0.05);33年回访复发率:观察组复发率42.9%VS 66.7%,低于对照组但差异无统计学意义(P>0.05)。结论:中西联合治疗甲状腺功能亢进症疗效可靠,可改善甲状腺功能,降低后期复发率,可作为甲状腺功能亢进治疗的优选方案。
Objective: To study the clinical effect of syndrome differentiation of traditional Chinese medicine combined with mepivacaazole in the treatment of hyperthyroidism and its effect on recurrence. Methods: Sixty-four patients with hyperthyroidism in our hospital were randomly divided into observation group and control group. All patients underwent western medicine (methimazole) treatment. The observation group was treated with TCM syndrome differentiation. The clinical efficacy, thyroid Function indicators: TRAB, TSH, TT3, TT4, FT3, free tetraiodothyronine Thyroid hormone (FT4)] and follow-up within 3 years the recurrence rate. (2) The thyroid function: After treatment, the TRAB (2.87 ± 1.54) IU / ml VS (4.61 ± 2.97) in the observation group was significantly higher than that in the observation group (3.51 ± 0.66) noml / L, TT4 (98.14 ± 31.90) noml / LVS (114.30 ± 29.46) noml / L and FT3 (7.16 ± 1.87) poml / L VS (9.11 ± 2.14) poml / L and FT4 (22.94 ± 5.31) poml / L VS (28.16 ± 6.24) poml / L, 0.49 ± 0.37) μIU / ml was significantly higher than that of the control group (P <0.05). The relapse rate of 33-year follow-up was 42.9% vs 66.7% in the observation group, but the difference was not statistically significant (P> 0.05). Conclusion: The combination of Chinese and western treatment of hyperthyroidism is reliable and can improve thyroid function and reduce the recurrence rate in the later stage. It can be used as the optimal treatment for hyperthyroidism.