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目的:对创伤患者血小板与红细胞比例对死亡率的影响进行META分析,确定创伤患者血小板的最佳比例。方法:检索1998年1月-2015年6月PUBMED,Cochrane Library,RCT注册网站关于创伤患者血小板与红细胞比例的临床效果进行对比分析的期刊文献,观察对象≥16周岁。涉及遗传性凝血因子缺陷或其他血液病问题的文章被排除。采用STATA12.0分析软件进行统计学分析。结果:3篇RCT论文纳入研究,856例病例。实施高血小板红细胞输血策略的患者为430例。高血小板红细胞输注比例对24 h和28 d死亡率无影响(24h RR 1.00,[95%CI,0.48 to 2.07),28d(RR 1.45,[95%CI,0.67 to 3.10)。结论 :高血小板红细胞输注增加24h止血率,但对24h和28d死亡率较常规输血策略无显著改变。
OBJECTIVE: To determine the optimal proportion of platelets in trauma patients by performing META analysis on the impact of the ratio of platelets to erythrocytes on mortality in trauma patients. METHODS: A literature review was conducted comparing the clinical outcomes of PUBMED, Cochrane Library, RCT registry websites on the proportion of platelets to erythrocytes in traumatic patients from January 1998 to June 2015. Subjects were ≥16 years of age. Articles dealing with hereditary clotting factor deficiencies or other blood diseases are excluded. Using STATA12.0 analysis software for statistical analysis. Results: Three RCT papers were included in the study and 856 cases were included. The implementation of high platelet transfusion strategy in patients with 430 cases. The rate of platelet RBC infusion had no effect on 24 h and 28 d mortality (24h RR 1.00, [95% CI, 0.48 to 2.07], 28 days (RR 1.45, [95% CI, 0.67 to 3.10]. CONCLUSION: High platelet transfusion increases the rate of hemostasis at 24 hours, but there is no significant difference in mortality at 24 and 28 days compared with conventional transfusion strategies.