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应用细胞因子基因转染的瘤苗进行肿瘤治疗是一条值得探讨的新途径。本研究将放射线灭活的ＴＮＦ－α基因转染的肿瘤细胞作为瘤苗联合低剂量ＩＬ－２和／或低剂量环磷酰胺治疗实验性肺转移荷瘤小鼠，结果发现单独应用ＴＮＦ基因转染的瘤苗无明显疗效，但联合低剂量ＩＬ－２或低剂量ＩＬ－２加低剂量环磷酰胺后具有显著的抗肿瘤转移作用。本研究表明，低剂量ＩＬ－２和低剂量环磷酰胺对ＴＮＦ基因转染瘤苗的抗肿瘤转移作用有增强效应。
The use of tumor gene transfected tumor vaccines for tumor treatment is a new approach worth exploring. In this study, tumor neoplasms transfected with radiation-activated TNF-α gene were used as tumor vaccines in combination with low-dose IL-2 and/or low-dose cyclophosphamide to treat experimental lung metastasis-bearing mice. The infected tumor vaccine has no obvious curative effect, but it has a significant anti-tumor metastasis effect when combined with low-dose IL-2 or low-dose IL-2 plus low-dose cyclophosphamide. This study shows that low-dose IL-2 and low-dose cyclophosphamide enhance the anti-tumor metastasis effect of TNF gene transfected tumor vaccines.