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目的 :研究芪丹通脉片 (QDTMT)对大鼠慢性心肌缺血预防作用及其机制 .方法 :采用SD大鼠为研究对象 ,比较观察QDTMT长期小剂量给药对异丙肾上腺素所致的心肌缺血保护作用 ,通过检测心肌血管内皮生长因子 (VEGF)、碱性成纤维细胞生长因子 (bFGF)表达 ,探讨其可能作用机制 .结果 :未注射ISO组未见VEGF ,bFGF表达 ,而在注射异丙肾上腺素 (Iso)各组VEGF ,bFGF表达均增加 ,给药组VEGF ,bFGF表达量高于未给药组 .结论 :QDTMT能够预防慢性心肌缺血 ,促进VEGF ,bFGF表达
Objective: To study the preventive effect of QDTMT on chronic myocardial ischemia in rats and its mechanism. Method: To observe the effects of long-term low-dose QDTMT on isoproterenol in SD rats. Myocardial ischemia protection, through the detection of myocardial vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) expression, to explore its possible mechanism of action. Results: no injection of VEGF, bFGF expression in the ISO group, but in The expression of VEGF and bFGF were increased in each group injected with isoproterenol (Iso). The expression of VEGF and bFGF in the treated group was higher than that in the untreated group. Conclusion: QDTMT can prevent chronic myocardial ischemia and promote the expression of VEGF and bFGF.