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单抗—化学药物偶联物导向治疗恶性肿癌的实验研究和临床应用,文献中已有记载,然而以CEA单抗—丝裂霉素C偶联物导向治疗晚期消化道癌肿尚未见报道.我们采用免疫活性高、特异性强的人结肠癌癌胚抗原单克隆抗体与丝裂霉素C制备成丝裂霉素C-癌胚抗原单抗原单抗偶联物C,(CEAmonoclonal antibody mitomycin C,简称
The experimental study and clinical application of monoclonal antibody-chemical drug conjugates for the treatment of malignant tumors have been described in the literature. However, the treatment of advanced gastrointestinal cancers with CEA monoclonal antibody-mitomycin C conjugates has not been reported. We used a monoclonal antibody against human colon cancer carcinoembryonic antigen with high specificity and specificity to prepare mitomycin C-carcinoembryonic antigen single antigen monoclonal antibody conjugate C (CEA monoclonal antibody mitomycin). C, abbreviation