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目的 :探讨血清和腹水中 CA— 50变化对消化系统恶性肿瘤的诊断价值。方法 :采用放射免疫法观察了 54例正常人 ,176例消化系统常见恶性肿瘤和 16 0例良性疾病病人血清 CA— 50含量。结果 :所测各种恶性肿瘤病人血清及腹水 CA— 50含量均显著高于正常人和相应脏器良性疾病病人 ;分别相比均有显著性差异 (P<0 .0 0 1)。良性疾病与正常人相比无显著性差异 (P>0 .0 5) ;且恶性肿瘤病人早期即有明显增高 ,晚期增高更为显著。结论 :血清和腹腔积液中 CA— 50的检测在消化系统良恶性疾病的诊断、鉴别诊断、病情估计 ,尤其是早期诊断和治疗后监测中均有一定实用价值。
Objective : To investigate the diagnostic value of CA 50 in serum and ascites for digestive system malignancy. Methods : The serum CA 50 content of 54 normal persons, 176 common malignant tumors in the digestive system and 160 benign diseases were observed by radioimmunoassay. Results: The serum and ascites CA 50 contents of all malignant tumor patients were significantly higher than those of normal and corresponding organs with benign diseases. There were significant differences (P < 0.01). There was no significant difference between benign disease and normal people (P>0.05). The patients with malignant tumors were significantly higher in early stage and more significant in late stage. Conclusion: The detection of CA 50 in serum and ascites has certain practical value in the diagnosis, differential diagnosis and disease assessment of the benign and malignant diseases of the digestive system, especially in the early diagnosis and post-treatment monitoring.