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在真核生物中,组蛋白乙酰化与去乙酰化在基因表达调控中起重要作用。组蛋白的乙酰化和去乙酰化修饰是一个与基因活化和抑制密切相关的动态过程,高乙酰化标志活跃转录而低乙酰化则与转录抑制相关。而组蛋白乙酰化酶(HATs)和组蛋白去乙酰化酶(HDACs)是组蛋白乙酰化的关键酶,其决定着组蛋白的乙酰化程度,参与了肿瘤异常基因表达。而抑癌基因通过对组蛋白赖氨酸末端的乙酰化修饰而改变染色体的结构,从而参与肿瘤的发生。脑胶质瘤是神经系统最常见的恶性肿瘤,其发生发展与抑癌基因的失活有关,而组蛋白的乙酰化水平与肿瘤的产生、增殖、致癌基因和肿瘤抑制基因的表达水平有密切的关系。因此现将抑癌基因的乙酰化与去乙酰化做一阐述。
In eukaryotes, histone acetylation and deacetylation play an important role in the regulation of gene expression. Acetylation and deacetylation of histone is a dynamic process that is closely related to gene activation and inhibition. High acetylation marks are active transcription and hypoacetylation is associated with transcriptional repression. Histone acetylation enzymes (HATs) and histone deacetylases (HDACs) are key enzymes of histone acetylation, which determine the degree of acetylation of histones and participate in the abnormal gene expression of tumors. The tumor suppressor gene by histone lysine end acetylation modification and change the chromosome structure, which participate in the tumor. Glioma is the most common malignant tumor of the nervous system. The occurrence and development of glioma is related to the inactivation of tumor suppressor gene. The histone acetylation level is closely related to the expression of tumorigenesis, proliferation, oncogenes and tumor suppressor genes Relationship. So now the anti-oncogene acetylation and deacetylation to do an elaboration.