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目的探讨伴有及不伴常见非器官特异性自身抗体的视神经脊髓炎谱系疾病(NMOSD)患者的临床特点。方法收集36例NMOSD患者,其中伴有常见非器官特异性自身抗体者26例(阳性组),不伴常见非器官特异性自身抗体者10例(阴性组),比较两组临床表现、实验室检查及影像学特点。结果 36例NMOSD患者中伴有至少一种常见非器官特异性自身抗体者占72.22%,并以抗核抗体、抗SSA抗体、抗Ro-52抗体为主。阳性组患者发病年龄晚于阴性组,且更易合并非器官特异性自身免疫疾病及肿瘤;阴性组患者首发症状中,视神经炎/脊髓炎比例明显高于阳性组,而阳性组的脑脊液压力及蛋白含量均明显高于阴性组;两组间其他临床、实验室及病灶分布特点相似。结论伴有常见非器官特异性自身抗体的NMOSD患者中枢神经系统炎症反应更严重,更易合并非器官特异性自身免疫疾病及肿瘤。
Objective To investigate the clinical features of optic neuromyelitis patients with and without common non-organ-specific autoantibodies. Methods Totally 36 patients with NMOSD were enrolled. Among them, 26 patients (positive group) with common non-organ specific autoantibodies and 10 non-common non-organ specific autoantibodies (negative group) were collected. The clinical manifestations, Inspection and imaging features. Results Of 36 patients with NMOSD, at least one common non-organ specific autoantibodies accounted for 72.22%, and were mainly anti-nuclear antibody, anti-SSA antibody and anti-Ro-52 antibody. Patients in the positive group were older than those in the negative group and were more likely to be associated with non-organ-specific autoimmune diseases and tumors. In the negative group, the proportion of optic neuritis / myelitis was significantly higher in patients with positive symptoms than in the positive group. The positive rates of cerebrospinal fluid pressure and protein Content were significantly higher than the negative group; other clinical, laboratory and lesion distribution characteristics are similar. Conclusions Patients with NMOSD associated with common non-organ specific autoantibodies have more severe central nervous system inflammation and are more likely to acquire non-organ-specific autoimmune diseases and tumors.