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目的 :探讨MHC -Ⅰ类抗原在口腔鳞癌中的表达及其意义。方法 :采用S -P免疫组化的方法 ,利用MHC -Ⅰ类抗原的单克隆抗体检测 47例口腔鳞癌组织中MHC -Ⅰ类抗原的表达。结果 :MHC -Ⅰ类抗原在各级口腔鳞癌中均有表达 ,且表达的阳性率随口腔鳞癌分化程度的下降而下降 ,在不同病理分级之间的阳性率有显著性差异 (P <0 .0 5 ) ,且与淋巴结转移及临床分期有关 (P <0 .0 5 )。结论 :MHC -Ⅰ类抗原可能作为口腔鳞癌发生、发展不同时期的一个标志物 ,并对判断口腔鳞癌的预后有一定价值 ,其在参与抗肿瘤免疫应答中的作用有待进一步探讨
Objective: To investigate the expression of MHC class I antigen in oral squamous cell carcinoma and its significance. Methods: The expression of MHC class I antigen in 47 cases of oral squamous cell carcinoma was detected by S-P immunohistochemistry and monoclonal antibody against MHC class I antigen. Results: The positive rate of MHC-Ⅰ antigen in all kinds of oral squamous cell carcinomas was lower than that of oral squamous cell carcinoma (P <0.05), and the positive rate of MHC-Ⅰ antigen was significantly different between different pathological grades (P < 0. 05), and lymph node metastasis and clinical stage (P <0. 05). Conclusion: MHC class I antigens may play an important role in the development of oral squamous cell carcinoma and develop markers of different stages, and have certain value in judging the prognosis of oral squamous cell carcinoma. The role of MHC-I antigen in anti-tumor immune response needs to be further explored